Premium
Linkage between the APOB gene and serum apoB levels in a large pedigree from the Bogalusa heart study
Author(s) -
Laing A. E.,
Amos C. I.,
DeMeester C.,
Diep A.,
Xia Y. R.,
Elston R. C.,
Srinivasan S. R.,
Berenson G. S.,
Lusis A. J.
Publication year - 1994
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370110104
Subject(s) - apolipoprotein b , genetics , biology , genetic linkage , major gene , gene , cholesterol , endocrinology
Maximum likelihood linkage analyses were performed to test for linkage between serum apoB levels and several candidate gene markers including apolipoprotein B, lipoprotein lipase, hepatic lipase, cholesterol ester transfer protein, and apolipoprotein AI in a large pedigree. Parameters of general Mendelian inheritance derived from maximum likelihood segregation analysis of the serum apoB levels were used in the linkage analysis. The highest two‐point lod score between the quantitative trait and a marker defined by a single restriction digest was 1.86 at recombination fraction (θ) = 0. This was observed for linkage between serum apoB levels and the presence or absence of a PvuII digestion site in the apoB gene. Linkage between serum apoB levels and polymorphisms of the apoB gene defined by the two restriction digests EcoR1 and PvuII was supported by a lod score of 3.30, while inclusion of VNTR typings led to a lod score of 2.33. None of the other candidate genes gave positive evidence of linkage. © 1994 Wiley‐Liss, Inc. This article is a US government work and, as such, is in the public domain in the United States of America.