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Segregation analysis for high density lipoprotein in the berkeley data
Author(s) -
Cupples L. Adrienne,
Myers Richard H.
Publication year - 1993
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370100650
Subject(s) - mendelian inheritance , data set , major gene , set (abstract data type) , biology , statistics , econometrics , genetics , mathematics , gene , computer science , programming language
Transmission models for high density lipoprotein (HDL) were evaluated in the Berkeley data set through segregation analyses using S.A.G.E. These preliminary analyses indicate that among the models fitted, an additive model with non‐Mendelian transmission probabilities provides a good fit for HDL, suggesting the possibility of a significant environmental component in the transmission of HDL. After adjustment for triglyceride, however, Mendelian models for a major gene seem to provide as good a fit as non‐Mendelian models but the results do not permit distinction between a dominant model and an additive model. © 1993 Wiley‐Liss, Inc.