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Two‐locus and bivariate segregation analysis of HDL‐C and apo AI
Author(s) -
Xu J. F.,
Prenger V. L.,
Coresh J.,
Beaty T. H.
Publication year - 1993
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370100646
Subject(s) - bivariate analysis , locus (genetics) , mendelian inheritance , univariate , major gene , genetics , biology , gene , multivariate statistics , statistics , mathematics
Two‐locus and bivariate segregation analyses of HDL‐C and apo AI were carried out using the GAW8 Berkeley data set. For HDL‐C, results are ambiguous. Both the mixed environmental model and the mixed Mendelian model fit the data equally well. For apo AI, however, univariate one‐locus segregation analysis suggests a Mendelian major gene controlling its levels. Moreover, two‐locus analysis suggests a second major gene is involved. Bivariate segregation analysis indicates these data cannot resolve the question as to whether a single Mendelian major gene with pleiotropic effects controls levels of both HDL‐C and apo AI in humans. © 1993 Wiley‐Liss, Inc.