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Effect of ignoring genotype‐environment interaction on segregation analysis of quantitative traits
Author(s) -
Tiret Laurence,
Abel Laurent,
Rakotovao Roger
Publication year - 1993
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370100642
Subject(s) - interaction , gene–environment interaction , genotype , gene interaction , biology , statistics , genetics , econometrics , mathematics , gene
Thirty replicates of 200 nuclear families (6 members each) were generated under three GxE interaction models. Segregation analyses of these data were performed using a regressive model taking into account an interaction effect or not. Results showed that ignoring the GxE interaction markedly decreased the power for accepting a major gene and led to serious bias in parameter estimates. © 1993 Wiley‐Liss, Inc.
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