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A novel polylocus method for linkage analysis using the lod‐score or affected sib‐pair method
Author(s) -
Terwilliger Joseph D.,
Ott Jurg
Publication year - 1993
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370100625
Subject(s) - linkage (software) , lod score , genetic linkage , statistics , computer science , point (geometry) , genetics , computational biology , biology , mathematics , gene mapping , gene , geometry , chromosome
A novel approach to combining data from multiple linked loci is proposed that can provide substantial increases in power over normal two‐point linkage analysis or sib‐pair analysis, with a substantial saving in computing time over traditional multipoint methods. © 1993 Wiley‐Liss, Inc.
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