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A two‐locus model for familial Alzheimer's disease?
Author(s) -
Macciardi Fabio,
Cavallini M. Cristina
Publication year - 1993
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370100618
Subject(s) - locus (genetics) , genetics , disease , biology , medicine , gene
The present findings for familial Alzheimer's disease suggest a possible linkage to gene(s) on chromosome 21 for the early onset form and to chromosome 19 for the late onset. Since these results are not unequivocal, possible alternative hypotheses include the effect of genetic heterogeneity or of an oligogenic model of segregation for FAD. © 1993 Wiley‐Liss, Inc.