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Linkage analysis of a complex disease: Application to familial Alzheimer's disease
Author(s) -
Neuman R. J.,
Rice J. P.,
Hampe C. L.,
Burroughs T. E.,
Moldin S. O.
Publication year - 1993
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370100615
Subject(s) - locus (genetics) , genetics , biology , genetic linkage , chromosome , disease , genetic marker , lod score , linkage (software) , chromosome 9 , gene , gene mapping , medicine
Abstract Evidence for linkage of the Alzheimer's gene to markers on chromosomes 19 and 21 was assessed using single‐locus and two‐locus models of inheritance. Families were divided into groups determined by their average age at onset. The youngest group produced higher lod scores for markers on chromosome 21 while an older group showed evidence for linkage to markers on chromosome 19. Two‐locus models of disease were used to analyze the youngest group for linkage to pairs of markers on chromosome 21 and an older group with markers on chromosome 19. © 1993 Wiley‐Liss, Inc.