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Linkage analysis of Alzheimer's disease with methods using relative pairs
Author(s) -
Blossey Heike,
Commenges Daniel,
Olson Jane M.
Publication year - 1993
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370100608
Subject(s) - pairwise comparison , linkage (software) , genetic linkage , correlation , statistics , lod score , genetics , mathematics , biology , gene , gene mapping , geometry , chromosome
Abstract Four relative‐pair methods for detecting genetic linkage were applied to familial Alzheimer's disease data. Results obtained using an extended Haseman‐Elston test and a weighted rank pairwise correlation test, which both use information from all relative pairs, were consistent with previously published likelihood results and appear to be more powerful than affected sib pair methods. © 1993 Wiley‐Liss, Inc.