Path analysis and sib‐pair linkage | Zendy

Carey Gregory | Zendy; Williamson John A. | Zendy

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Path analysis and sib‐pair linkage

Author(s) -

Carey Gregory,

Williamson John A.

Publication year - 1993

Publication title -

genetic epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.301

H-Index - 98

eISSN - 1098-2272

pISSN - 0741-0395

DOI - 10.1002/gepi.1370100203

Subject(s) - linkage (software) , identity by descent , recombination fraction , covariance matrix , covariance , genetics , correlation , genetic linkage , path coefficient , biology , mathematics , statistics , path (computing) , path analysis (statistics) , combinatorics , gene mapping , chromosome , gene , computer science , haplotype , allele , geometry , programming language

When the distance between linked loci is expressed in terms of the correlation between the identity‐by‐descent (idb) values of the loci, then a path model may be used to order loci with data on sib‐pairs and their parents. The relationship between the recombination fraction and the correlation coefficient is developed and a method for fitting a covariance matrix predicted by a specific ordering of loci to an observed covariance matrix is proposed. © 1993 Wiley‐Liss. Inc.

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