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Path analysis and sib‐pair linkage
Author(s) -
Carey Gregory,
Williamson John A.
Publication year - 1993
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370100203
Subject(s) - linkage (software) , identity by descent , recombination fraction , covariance matrix , covariance , genetics , correlation , genetic linkage , path coefficient , biology , mathematics , statistics , path (computing) , path analysis (statistics) , combinatorics , gene mapping , chromosome , gene , computer science , haplotype , allele , geometry , programming language
When the distance between linked loci is expressed in terms of the correlation between the identity‐by‐descent (idb) values of the loci, then a path model may be used to order loci with data on sib‐pairs and their parents. The relationship between the recombination fraction and the correlation coefficient is developed and a method for fitting a covariance matrix predicted by a specific ordering of loci to an observed covariance matrix is proposed. © 1993 Wiley‐Liss. Inc.