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Sensitivity of transmission probabilities to paternity exclusion in segregation analysis
Author(s) -
Bonaïtipellié Catherine,
Poisson Nicole,
Bechtel Yvette,
Bechtel Pierre,
Vogler G. P.
Publication year - 1992
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370090108
Subject(s) - sensitivity (control systems) , statistics , transmission (telecommunications) , biology , mathematics , genetics , computer science , engineering , telecommunications , electronic engineering
Paternity exclusions are known to be common in Western countries and are yet neglected in segregation analysis because it is almost impossible to check it systematically on a large family sample. We had the opportunity of observing the sensitivity of segregation analysis parameters to a paternity exclusion in analyzing 34 families for a simple Mendelian trait, the acetylator phenotype. We found that only one family, with proven paternity exclusion, was responsible for a strong rejection of Mendelian transmission probabilities ( P ≪0.001). © 1992 Wiley‐Liss, Inc.