Premium
Blood pressure and other cardiovascular disease risk factors in black adults with sickle cell trait or glucose‐6‐phosphate dehydrogenase deficiency
Author(s) -
Nwankwo Martin U.,
Bunker Clareann H.,
Ukoli Flora A.,
Omene Jackson A.,
Freeman Donald T.,
Vergis Emanuel N.,
Yeh Lan Lan,
Kuller Lewis H.,
Rao D. C.
Publication year - 1990
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370070305
Subject(s) - sickle cell trait , medicine , endocrinology , microalbuminuria , blood pressure , glucose 6 phosphate dehydrogenase deficiency , high density lipoprotein , cholesterol , risk factor , negroid , glycogen storage disease type i , obesity , physiology , disease , epidemiology , glycogen storage disease
In this study, we examined the relationship of two common genetic markers in black populations, sickle cell trait and glucose‐6‐phosphate dehydrogenase (G‐6‐PD) deficiency, to cardiovascular risk factors. The subjects were Nigerian civil servants in Benin City, Nigeria. We measured blood pressure, height, weight, sickle cell hemoglobin, G‐6‐PD, proteinuria, microalbuminuria and fasting serum cholesterol, high‐density lipoprotein cholesterol (HDL), triglycerides, apoprotein (APO) AI, and APO B. Data were collected on age, alcohol consumption, cigarette smoking, job status, and years lived in an urban area. There were 257 males (3 SS hemoglobin, 73 AS, 181 AA) and 69 females (23 AS, 46 AA). In comparing cardiovascular risk factors, males differed only in percent of smokers (31.5 in AS vs. 17.8 in AA, P < 0.01). Among females, only high‐density lipoprotein (HDL) cholesterol differed (61.5 mg/dl in AS vs. 52.4 in AA, P < 0.01). We hypothesize that females with sickle cell trait are more likely to use oral contraceptives than nontrait females. If so, the high‐estrogen oral contraceptives available in Nigeria could elevate HDL. G‐6‐PD deficiency status among males (52 deficient, 207 nondeficient) and females (1 deficient, 5 carriers, 65 nondeficient) was not related to any of the cardiovascular risk factors. We conclude that sickle cell hemoglobin trait and G‐6‐PD deficiency are not useful genetic markers for risk factors for cardiovascular disease.