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Evolution of the Pittsburgh studies of the epidemiology of insulin‐dependent diabetes mellitus
Author(s) -
Kuller Lewis H.,
Becker Dorothy J.,
Cruickshanks Karen J.,
Dorman Janice S.,
Eberhardt Mark S.,
Drash Allan L.,
LaPorte Ronald E.,
Lipton Rebecca,
Moy Claudia,
O'Leary Leslie A.,
Orchard Trevor J.,
Rewers Marian,
Songer Thomas,
Tajima Naoko,
Trucco Massimo,
Wagener Diane,
Spielman R. S.
Publication year - 1990
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370070202
Subject(s) - epidemiology , diabetes mellitus , genetic epidemiology , population , disease , etiology , genetic predisposition , medicine , bioinformatics , genetics , biology , environmental health , endocrinology
The Pittsburgh project evaluating the epidemiology and etiology of insulin‐dependent diabetes mellitus (IDDM) is currently one of the large ongoing studies of childhood diabetes. This paper traces the evolution of the project, from the initial basic epidemiologic approach in the early 1980s, to the current thrust where complex molecular genetic approaches are being incorporated into population‐based research. The epidemiology models employed in the Pittsburgh project are similar to those that could be used in many areas of chronic disease research. The integration of immunogenetics into epidemiology produces a powerful approach for understanding the complex interaction of host susceptibility and environmental agents that contribute to the development of IDDM.