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Genetic linkage and complex diseases, with special reference to psychiatric disorders
Author(s) -
Risch Neil,
Rao D. C.
Publication year - 1990
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370070103
Subject(s) - linkage (software) , genetics , genetic linkage , psychiatry , medicine , biology , gene
Recent linkage findings for psychiatric disorders, in particular schizophrenia, manic‐depression, and Alzheimer disease, have raised a number of important conceptual issues regarding the genetic etiology of these diseases, as well as the appropriate interpretation of linkage results in studying complex diseases. Perspectives on mode of inheritance, genetic heterogeneity, and phenotypic variation are given.