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Complex segregation analysis for a three‐allele locus: Experience from an analysis of acid phosphatase activity
Author(s) -
Iselius L.,
Evans D. A. P.,
Eze L. C.,
Tweedie M. C. K.,
Bullen M. F.,
Wren P. J. J.,
Rao D. C.
Publication year - 1989
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370060506
Subject(s) - acid phosphatase , locus (genetics) , allele , phosphatase , gene , genetics , biology , allele frequency , polymorphism (computer science) , microbiology and biotechnology , biochemistry , enzyme , phosphorylation
A complex segregation analysis of acid phosphatase activity in 50 British families showed that the essential features of the acid phosphatase polymorphism, i.e., a major gene with three alleles, is retrieved by using the biallelic mixed model. The estimates of gene frequency and displacement obtained from segregation analysis were in agreement with those obtained from electrophoretic studies. In addition, there was evidence for a multifactorial component.