Premium
Phenylthiocarbamide taste sensitivity revisited: Complete sorting test supports residual family resemblance
Author(s) -
Reddy B. M.,
Rao D. C.,
MacCluer Jean W.
Publication year - 1989
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370060304
Subject(s) - heritability , residual , dominance (genetics) , sorting , locus (genetics) , statistics , analysis of variance , taste , mathematics , biology , genetics , food science , algorithm , gene
Phenylthiocarbamide (PTC) taste thresholds were determined in 100 nuclear families using the complete sorting test. Segregation analysis using the mixed model suggested that the variability in PTC thresholds is controlled by a major locus with incomplete dominance as well as by a multifactorial component with significant residual heritability. Such a model explained nearly 96% of the variance, leaving only 4% of the variance in thresholds arising from measurement error and other environmental factors.