z-logo
Premium
Phenotypic effects of apolipoprotein structural variation on lipid profiles. I. APO H and quantitative lipid measures in the healthy women study
Author(s) -
Eichner J. E.,
Kuller L. H.,
Kamboh M. I.,
Ferrell R. E.,
Vogler G. P.,
Rao D. C.
Publication year - 1989
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370060202
Subject(s) - apolipoprotein b , biology , allele , phenotype , lipoprotein , apolipoprotein e , genetics , medicine , endocrinology , population , polymorphism (computer science) , cholesterol , gene , disease , environmental health
Apolipoprotein H (APO H), also known as β 2 ‐glycoprotein I, has been identified as a protein component of the major lipoprotein density fractions in human plasma. Recently, genetically determined structural polymorphism in white and black populations has been documented for this apolipoprotein. There are three common alleles in whites and blacks and a fourth allele found mainly in blacks. Family data confirm the autosomal codominant pattern of inheritance for the APO H structural gene. Little is known about the function of APO H, but it has demonstrated both lipid and platelet involvement. In this study we investigate the effect of APO H phenotypes on quantitative lipid measures in a group of 443 white women being followed through menopause for changes in cardiovascular risk. At baseline all women were premenopausal. None of the APO H phenotypes showed a statistically significant effect on lipid measures in this population.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here