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HLA may be involved in resistance and susceptibility to affective disorders
Author(s) -
Payami H.,
Dubay C.,
Valenzuela R. Carrero
Publication year - 1989
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370060151
Subject(s) - human leukocyte antigen , linkage (software) , genetics , genetic linkage , haplotype , genetic predisposition , genetic association , biology , linkage disequilibrium , family studies , allele , antigen , genotype , single nucleotide polymorphism , gene
The role of HLA in susceptibility to affective disorders was assessed by sib pair linkage analysis and by association studies. Unipolar Disorder (UD) and Bipolar Disorder (BD) were studied separately. Both the sib pair data and the antigen frequency distribution suggested an HLA‐linked susceptibility to UD. For BD however, the HLA haplotype sharing distribution in sib pairs was random, but the antigen frequencies suggested at least one positive association and one negative association with HLA. The lack of evidence for linkage to HLA from sib pairs may have been due to the genetic heterogeneity of BD.