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Linkage data on affective disorders in an epidemiologic context
Author(s) -
Gershon Elliot S.,
Goldin Lynn R.
Publication year - 1989
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370060136
Subject(s) - locus (genetics) , genetics , genetic linkage , linkage (software) , biology , context (archaeology) , cohort , medicine , gene , paleontology
Recent data on chromosomal linkage markers in affective disorders indicate that single locus inheritance is involved in these disorders. The presence of a single locus has not been detectable using segregation analysis on family study data from large populations, possibly because of both heterogeneity and birth cohort and sex differences in diagnostic frequencies.