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HLA DQβ3.2 identifies subtypes of DR4 + haplotypes permissive for IDDM
Author(s) -
Robinson David M.,
Holbeck Susan,
Palmer Jerry,
Nepom Gerald T.
Publication year - 1989
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370060128
Subject(s) - permissive , haplotype , genetics , human leukocyte antigen , biology , allele , gene , antigen
The HLA class II‐related susceptibility to type I insulin‐dependent diabetes mellitus (IDDM) is examined in 94 multiplex families sorted by the presence or absence of a DR4+ haplotype in at least one diabetic family member. The families with DR4+ haplotypes are then sorted by the presence or absence of a DR4‐linked DQβ3.2 allele. Further analysis assumes each multiplex family to represent a single diabetic genetic event and identifies the HLA class II haplotype(s) present in all affected members. The DQβ3.2 allele is present in over 95% of the multiplex families where DR4+ haplotypes segregate with IDDM, implying a major permissive role in determining susceptibility to IDDM.