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Combined segregation and linkage analysis for IDDM and HLA‐DR under several ascertainment assumptions
Author(s) -
Pascoe Leigh,
Sherman Stephanie,
Wu Danny,
Becker Murray,
Falk Catherine
Publication year - 1989
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370060125
Subject(s) - human leukocyte antigen , genetics , locus (genetics) , allele , genetic linkage , linkage (software) , biology , gene , allele frequency , antigen
Combined segregation and linkage analysis of the Genetic Analysis Workshop 5 (GAW5) data suggests a complex basis for susceptibility to insulin‐dependent diabetes mellitus (IDDM). One susceptibility gene, linked to the HLA‐DR region, is additive on the liability scale (d = .49 ± .15,t = 2.9 ± .6) with a gene frequency q = .30 ± .03. A second locus, with a gene frequency of q = .07 ± .02, which is recessive and unlinked to HLA, is also suggested by the analysis. The ascertainment correction used has little effect on the results, presumably because most of the information comes from the cosegregation of HLA alleles and disease status. The results are consistent with a direct involvement of the HLA‐DR region in susceptibility, but are not a proof of it.