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Genetic analysis of IDDM: The GAW5 multiplex family dataset
Author(s) -
Baur M. P.,
Fimmers R.,
Fritsche C.,
Hümmelink M.,
Neugebauer M.,
Acton R. T.,
Hodge T.,
Barbosa J.,
Bertrams J.,
Fehsel K.,
Kolb H.,
Rothe H.,
Boehm B.,
CambonThomsen A.,
Avoustin P.,
Coppin H.,
Darnaud J.,
Massabie P.,
Ohayon E.,
de Preval C.,
Tauber J. P.,
Thomsen M.,
Colle E.,
MacDonald M. J.,
Nevin D.,
Gottschall J. L.,
Nepom G. T.,
Robinson D. M.,
Holbeck S.,
Palmer J. P.,
Nerup J.,
Rotter J. I.,
Vadheim C.,
Rittner C.,
Schneider P.,
Sheehy M. J.,
Cox N. J.,
Baker L.,
Spielman R. S.
Publication year - 1989
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370060105
Subject(s) - multiplex , genetics , computational biology , biology
In a collaborative effort by 12 centers from Europe and North America, data were assembled from 94 multiplex families with insulin‐dependent diabetes mellitus (IDDM) for analysis of genetic and other factors of possible etiological importance. The dataset contains information on the following genetic markers: HLA‐DRß and ‐DQß restriction fragment length polymorphisms (RFLPs), three RFLPs detected with two probes that map 5′ to the insulin gene, the serologically defined HLA loci, and the immunoglobulin allotypes. Data also were included for auto‐antibodies to insulin and pancreatic islet cells as possible indicators of pathogenesis and for antibodies to certain viruses that have been implicated as “triggering” agents in IDDM. Medical histroy of family members was obtained by means of a uniform questionnaire. Identical copies of the dataset were distributed to anyone wishing to participate in the analysis for the IDDM component of GAW5. The multiplex IDDM family dataset is now available on request for further analysis.