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Partial linkage map of chromosome 13q in the region of the Wilson disease and retinoblastoma genes
Author(s) -
Haines Jonathan L.,
Ozelius Laurie,
GeorgeHyslop Peter St,
Wexler Nancy S.,
Gusella James F.,
Conneally P. Michael,
Vogler G. P.
Publication year - 1988
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370050602
Subject(s) - linkage (software) , retinoblastoma , genetics , genetic linkage , chromosome , biology , chromosome 13 , gene
Abstract Genetic linkage maps are useful tools for defining the location of disease genes. Previously published maps of human chromosome 13 have been incomplete and have had ambiguities of order in the vicinity of the Wilson disease (WND) and retinoblastoma (RBl) genes. We have defined a six‐locus map of this region using a large reference pedigree from Venezuela. Our map provides landmarks which will aid in the localization of WND, in determining the extent of deletions in retinoblastoma, and in the mapping of other marker loci.