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Cytogenetic studies of couples with repeated spontaneous abortions of known karyotype
Author(s) -
Hassold Terry,
Jacobs Patricia A.,
Pettay Dorothy,
Rao D. C.
Publication year - 1988
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370050202
Subject(s) - aneuploidy , karyotype , peripheral blood , chromosome , biology , trisomy , products of conception , abortion , fetus , cytogenetics , induced abortions , andrology , genetics , pregnancy , gynecology , obstetrics , medicine , population , research methodology , immunology , family planning , gene , environmental health
Several cytogenetic studies have reported an increased frequency of aneuploidy in peripheral blood cultures of couples with multiple spontaneous abortions. However, in none of the studies have the chromosome constitutions of the fetuses been known, making it difficult to interpret these observations. In the present study, we summarize our cytogenetic observations on 23 couples with multiple miscarriages, 12 of whom had repeated chromosomally normal spontaneous abortions, and 11 repeated trisomic spontaneous abortions. We were unable to demonstrate a significant difference in the level of aneuploidy between the two groups. Therefore, it seems unlikely that aneuploidy detectable in peripheral blood preparations is an important indicator of fetal aneuploidy.