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Further tests of nonrandom segregation with special reference to linkage
Author(s) -
Majumder Partha P.,
Rao D. C.
Publication year - 1987
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370040507
Subject(s) - linkage (software) , genetic linkage , genetics , biology , haplotype , statistical hypothesis testing , statistics , mathematics , allele , gene
For an autosomal recessive disease, a statistical procedure is developed for detecting nonrandom segregation of marker haplotypes from an unaffected parent to affected children, specifically for the case when the alternative hypothesis of linkage between the disease and marker loci is postulated. The test procedure is locally most powerful and, depending on family size and number of families sampled, any one of the three test statistics proposed can be used. An application of this procedure provides evidence of linkage between tuberculoid leprosy and HLA.