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Association between polymorphic blood markers and risk factors for cardiovascular disease in a large pedigree
Author(s) -
George Varghese T.,
Elston Robert C.,
Amos Chris I.,
Ward Laura J.,
Berenson Gerald S.,
Rao D. C.
Publication year - 1987
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370040405
Subject(s) - abo blood group system , allele , biology , locus (genetics) , genetics , medicine , disease , gene
A large pedigree with high prevalence of heart disease is investigated to analyse the association between polymorphic blood markers and quantitative risk factors for cardiovascular disease. The analysis incorporates a familial correlation structure among the individuals in the pedigree and a generalized power transformation to induce approximate residual normality of the risk factors. A total of 380 marker/ risk factor combinations are analysed, and at the nominal 1 % significance level, positive associations are found between the A antigen of the ABO locus and both serum total cholesterol and low‐density lipoprotein cholesterol, and negative associations are found between the B antigen of the ABO locus and serum total cholesterol, and between the B allele of acid phosphatase (AP) locus and systolic blood pressure.