Association between polymorphic blood markers and risk factors for cardiovascular disease in a large pedigree | Zendy

George Varghese T. | Zendy; Elston Robert C. | Zendy; Amos Chris I. | Zendy; Ward Laura J. | Zendy; Berenson Gerald S. | Zendy; Rao D. C. | Zendy

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Association between polymorphic blood markers and risk factors for cardiovascular disease in a large pedigree

Author(s) -

George Varghese T.,

Elston Robert C.,

Amos Chris I.,

Ward Laura J.,

Berenson Gerald S.,

Rao D. C.

Publication year - 1987

Publication title -

genetic epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.301

H-Index - 98

eISSN - 1098-2272

pISSN - 0741-0395

DOI - 10.1002/gepi.1370040405

Subject(s) - abo blood group system , allele , biology , locus (genetics) , genetics , medicine , disease , gene

A large pedigree with high prevalence of heart disease is investigated to analyse the association between polymorphic blood markers and quantitative risk factors for cardiovascular disease. The analysis incorporates a familial correlation structure among the individuals in the pedigree and a generalized power transformation to induce approximate residual normality of the risk factors. A total of 380 marker/ risk factor combinations are analysed, and at the nominal 1 % significance level, positive associations are found between the A antigen of the ABO locus and both serum total cholesterol and low‐density lipoprotein cholesterol, and negative associations are found between the B antigen of the ABO locus and serum total cholesterol, and between the B allele of acid phosphatase (AP) locus and systolic blood pressure.

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