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Two‐disease locus model: Sib pair method using information on both HLA and Gm
Author(s) -
Dizier M. Hélène,
ClergetDarpoux Françoise,
Rao D. C.
Publication year - 1986
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370030507
Subject(s) - locus (genetics) , human leukocyte antigen , multiplicative function , genetics , biology , mathematics , gene , antigen , mathematical analysis
An adaptation of the sib pair method is given for testing the independence of transmission of Gm and the disease, using variable X (which gives information on the phenotypic identity of a sib pair for Gm). Then the joint distribution of IBD for HLA and X for Gm among affected sib pairs was derived under different two‐locus models (multiplicative and other) in which one locus is strictly linked to HLA and the other to Gm. We also propose a test for a joint effect of HLA and Gm and whether this effect is multiplicative or not.