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Description of a large pedigree with an adverse lipoprotein cholesterol phenotype: The Bogalusa Heart Study
Author(s) -
Rosenbaum Peter A.,
Amos Christopher I.,
Shear Charles L.,
Elston Robert C.,
Sellers Thomas A.,
Srinivasan Sathanur R.,
Berenson Gerald S.,
Rao D. C.
Publication year - 1986
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370030405
Subject(s) - lipoprotein , medicine , cholesterol , endocrinology , very low density lipoprotein , lipoprotein(a) , biology , adverse effect , offspring , genetics , pregnancy
A large pedigree (N = 356) with a high prevalence of heart disease and associated adverse lipoprotein phenotype was studied. The adverse lipoprotein phenotype is characterized by both low levels of high‐density‐lipoprotein cholesterol (HDL‐C) alone (16.3%) and in combination with other adverse lipoprotein levels (12.8%). In all, 44.2% of all pedigree members had at least one adverse lipoprotein level. Analysis of mating types showed that all lipids and lipoproteins possess familial clustering with 25–36% of offspring above median levels when both parents had levels below the median, while 67–83% had levels above the median when both parents had levels above the median. Using adjusted lipid and lipoprotein levels, a statistically significant linear trend was found between the degree of relationship to pedigree members with heart disease, and both the low‐density‐lipoprotein cholesterol/high‐density‐lipoprotein cholesterol (LDL‐C/HDL‐C) ratio (P < .05), and the very‐low‐density‐lipoprotein cholesterol (VLDL‐C; P < .01) level. A similar analysis using the prevalence of adverse lipoprotein levels as the dependent variable and degree of relationship to heart diseased pedigree numbers as the independent variable showed significant (P < .05) relationships with VLDL‐C and the LDL‐C/HDL‐C ratio. Further genetic analyses of this pedigree may reveal genetic mechanisms responsible for the familiality of lipoprotein levels in this pedigree.