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Studies on an isolated West Indies population: IV. Genetic study of hearing loss
Author(s) -
Bonaïti Catherine,
Demenais Florence,
Bois Etienne,
Hochez Joelle,
Rao D. C.
Publication year - 1986
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370030206
Subject(s) - west indies , hearing loss , genetics , population , biology , gene , genetic analysis , audiology , demography , medicine , ethnology , history , sociology
Hearing troubles were found to be very frequent among inhabitants of French origin in a small Caribbean island. Segregation analysis of hearing loss was performed in 165 complete nuclear families and revealed that familial aggregation could be entirely explained by a single recessive gene with high frequency (0.40). Homozygous individuals for this gene would probably be more susceptible to ototoxic agents than other individuals. High frequency of this gene may be due to a founder effect.