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Construction of human linkage maps: Likelihood calculations for multilocus linkage analysis
Author(s) -
Lathrop G. M.,
Lalouel J. M.,
White R. L.,
Rao D. C.
Publication year - 1986
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370030105
Subject(s) - linkage (software) , genetic linkage , genetics , biology , complete linkage , grandparent , human genome , chromosome , computational biology , genome , evolutionary biology , gene , psychology , developmental psychology , genotype , single nucleotide polymorphism
Methods are given for efficient calculation of the likelihood for multilocus linkage in families comprised of grandparents, parents, and children. Such families are being used in large‐scale cooperative efforts to build a detailed linkage map of the human genome. The methods are illustrated by an application to loci on chromosome 13.