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Segregation analysis of hereditary nonpolyposis colorectal cancer
Author(s) -
BaileyWilson Joan E.,
Elston Robert C.,
Schuelke Guy S.,
Kimberling William,
Albano William,
Lynch Jane F.,
Lynch Henry T.,
Rao D. C.
Publication year - 1986
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370030104
Subject(s) - colorectal cancer , endometrial cancer , cancer , medicine , oncology , biology
Segregation analysis of eleven families comprising 2762 individuals indicated compatibility of the data with segregation of a major autosomal dominant gene for hereditary nonpolyposis colorectal cancer. It was estimated that between 71% and 79% of the gene carriers were susceptible and had age of onset that was normally distributed with mean about 47 and standard deviation about 10 years. There was a low frequency of sporadic cases at the older ages, a little less than four percent of nongene carriers being affected by age 80. No significant differences were found between the families exhibiting endometrial cancer (cancer family syndrome) and those not exhibiting endometrial cancer (hereditary site‐specific nonpolyposis colonic cancer).