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Effects of household sharing on high density lipoprotein and its subfractions
Author(s) -
Hasstedt Sandra J.,
Kuida Hiroshi,
Owen Ash K.,
Williams Roger R.,
Rao D. C.
Publication year - 1985
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370020403
Subject(s) - pedigree chart , high density lipoprotein , variance components , analysis of variance , offspring , variance (accounting) , biology , cholesterol , lipoprotein , medicine , demography , endocrinology , genetics , statistics , mathematics , gene , pregnancy , accounting , business , sociology
Household effects accounted for significant proportions of the observed variance of high density lipoprotein cholesterol (HDL‐C) and subfractions HDL 2 and HDL 3 . It was found that 19.3% of HDL‐C variance could be attributed to a juvenile sib effect (under age 18); 17.4% of HDL 2 variance could be attributed to a sib effect (of any age); and 22.1% and 32.6% of the HDL 3 variance could be attributed to a parent‐offspring effect and a sib effect (of any age), respectively. In addition, additive genetic effects accounted for 56.5%, 37.3%, and 28.3% of the variances of HDL‐C, HDL 2 , and HDL 3 , respectively. These are maximum likelihood estimates obtained using a variance components model on 2,149 HDL‐C levels measured on members of 54 Utah pedigrees, and 337 HDL 2 and HDL 3 levels measured on a subset of 14 pedigrees.