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Genetic analysis workshop III: Combining two‐point analyses under the constraints of a linear map and a constant female/male distance ratio
Author(s) -
Ott Jurg
Publication year - 1985
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370020219
Subject(s) - bivariate analysis , statistics , mathematics , pairwise comparison , constant (computer programming) , restricted maximum likelihood , linkage (software) , lod score , correlation , genetic distance , maximum likelihood , biology , combinatorics , genetics , gene mapping , genetic variation , gene , computer science , geometry , chromosome , programming language
For each pair of loci among the four loci in a linkage group, a two‐point analysis was performed. It consisted of estimating means, variances, and correlation of male and female recombination fractions and approximating the joint likelihood by a bivariate normal density. The pairwise results were assumed independent and combined. The resulting likelihood was maximized over five parameters: three map distances, a constant ratio of female‐to‐make distance, and the parameter in Felsenstein's mapping function.