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A comparison of sib‐pair linkage tests for disease susceptibility loci
Author(s) -
Blackwelder William C.,
Elston Robert C.,
Rao D. C.
Publication year - 1985
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370020109
Subject(s) - locus (genetics) , identity by descent , genetics , linkage (software) , genetic linkage , biology , pedigree chart , allele , statistics , sample size determination , lod score , mathematics , gene mapping , haplotype , gene , chromosome
An analytical study is conducted of the properties of statistical tests to detect linkage between a disease locus and a very polymorphic marker locus when data on sib pairs are available. In most instances the most powerful test is the test based on the mean number of marker alleles shared identical by descent by the two members of a sib pair, and the most efficient sampling strategy is almost always to sample only pairs with both sibs affected. We show it is valid to use the information from all possible sib pairs as though they came from separate families when data on sibships of size three or larger are available, though more power may be obtained if different weights are given to the different sibship sizes.