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Interpretation of LOD scores with a set of marker loci
Author(s) -
Thompson E. A.,
Nance Walter E.
Publication year - 1984
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370010407
Subject(s) - lod score , locus (genetics) , linkage (software) , interpretation (philosophy) , genetics , set (abstract data type) , genetic linkage , mathematics , statistics , biology , gene mapping , computer science , gene , chromosome , programming language
The problem discussed is that of interpreting LOD scores when multiple markers are tested for linkage with a particular disease locus. Provided the tests are based on independent segregations, both the maximum and the average LOD can be translated into a score that would have the same significance level were it the result of a single test.
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