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Complete hydatidiform mole in Hawaii: An epidemiological study
Author(s) -
Matsuura Janice,
Chiu Darryl,
Jacobs Patricia A.,
Szulman A. E.,
Rao D. C.
Publication year - 1984
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370010306
Subject(s) - etiology , epidemiology , incidence (geometry) , race (biology) , mole , partial hydatidiform mole , demography , socioeconomic status , medicine , significant difference , gynecology , pregnancy , obstetrics , biology , pathology , fetus , genetics , population , environmental health , placenta , botany , physics , sociology , optics
An analysis of hydatidiform moles occurring in Hawaii over a 14‐year period (1968–1981) was undertaken. The pathology of all 278 reported molar pregnancies was reviewed and showed 69.4% to be complete, 24.5% to be partial, and 6.1% to be nonmolar. A case‐control epidemiological investigation of the complete moles showed maternal age and race to be important, moles being significantly more prevalent in women under 20 and over 40 yr of age and also in women of Japanese, Filipino, and other Oriental ancestry. However no difference was seen in the prevalence of moles between Oriental women born in the Orient and those born and raised in Hawaii. No significant difference was found in paternal age, paternal race, socioeconomic status, or reproductive history, suggesting that these factors do not play an important role in the etiology of complete hydatidiform mole. Incidence rates for complete moles were calculated taking age and race into consideration and ranged from a high of 1 in 150 to a low of 1 in 2,000 naturally terminating pregnancies.