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Genetic analysis workshop II: Further consideration of segregation and linkage analyses in problem 3
Author(s) -
Kramer P. L.,
Altmann D. B.,
Kidd K. K.
Publication year - 1984
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370010213
Subject(s) - mendelian inheritance , trait , quantitative trait locus , linkage (software) , genetic linkage , genetics , locus (genetics) , biology , genetic analysis , computational biology , computer science , gene , programming language
We analyzed disease‐marker associations in Problem 3 for the Genetic Analysis Workshop II, using PAP for segregation analysis and LIPED for linkage analysis. In this report we present aspects of our analyses that are not reported in the summary [MacCluer et al, 1984]. Certain features that we added to the running of LIPED to facilitate the analyses are discussed. Furthermore, we tested for Mendelian transmission in the hypothetical trait locus and we calculated modified relative risks for marker‐trait genotypes. Some of the problems involved in analyzing complex associations among loci are discussed.