Genetic analysis workshop II: Results of incorporating a linkage disequilibrium parameter | Zendy

Goldgar David E. | Zendy; Fain Pamela R. | Zendy

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Genetic analysis workshop II: Results of incorporating a linkage disequilibrium parameter

Author(s) -

Goldgar David E.,

Fain Pamela R.

Publication year - 1984

Publication title -

genetic epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.301

H-Index - 98

eISSN - 1098-2272

pISSN - 0741-0395

DOI - 10.1002/gepi.1370010211

Subject(s) - linkage disequilibrium , linkage (software) , disequilibrium , genetic linkage , genetics , biology , evolutionary biology , allele , haplotype , gene , medicine , ophthalmology

The incorporation of a linkage disequilibrium parameter, Δ, into linkage analysis is illustrated for data from Genetic Analysis Workshop II. Points from a joint likelihood surface are calculated and displayed on a recombination fraction‐linkage disequilibrium grid using a simple modification of LIPED. The approach is shown to increase the power of linkage analysis and the power of tests for heterogeneity of linkage for the simulated examples.

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