Premium
Genetic analysis workshop II: Results of incorporating a linkage disequilibrium parameter
Author(s) -
Goldgar David E.,
Fain Pamela R.
Publication year - 1984
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370010211
Subject(s) - linkage disequilibrium , linkage (software) , disequilibrium , genetic linkage , genetics , biology , evolutionary biology , allele , haplotype , gene , medicine , ophthalmology
The incorporation of a linkage disequilibrium parameter, Δ, into linkage analysis is illustrated for data from Genetic Analysis Workshop II. Points from a joint likelihood surface are calculated and displayed on a recombination fraction‐linkage disequilibrium grid using a simple modification of LIPED. The approach is shown to increase the power of linkage analysis and the power of tests for heterogeneity of linkage for the simulated examples.