Premium
Genetic analysis workshop II: Sib pair screening tests for linkage
Author(s) -
Elston R. C.
Publication year - 1984
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370010210
Subject(s) - linkage (software) , genetics , genetic linkage , biology , statistics , genealogy , evolutionary biology , mathematics , history , gene
For each marker locus and for every pair of sibs with data available in the 1983 workshop data, the proportion of genes identical by descent was estimated. The mean proportions were compared between concordant and discordant sib pairs, and the mean proportion for concordantly affected pairs was compared with one half. Together with standard tests of association, these were found to be sensitive screening tests for linkage.