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Genetic analysis workshop II: Study of problem 2 linkage relationships by different methods
Author(s) -
Demenais F.,
Darlu P.
Publication year - 1984
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.1370010209
Subject(s) - locus (genetics) , genetic linkage , linkage (software) , genetics , biology , lod score , computational biology , gene mapping , gene , chromosome
Segregation and linkage analyses were performed on Problem 2 simulated data. Segregation analysis showed evidence for a nearly recessive major susceptibility locus with parameter estimates close to the simulation input values. Linkage analyses between this susceptibility locus (X) and the ten marker loci (A to J) led us to propose the following map: X‐G‐F‐B.