Premium
The estimation of sibling genetic risk parameters revisited
Author(s) -
Zou Guohua,
Zhao Hongyu
Publication year - 2004
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.10322
Subject(s) - estimator , sibling , statistics , estimation , variance (accounting) , econometrics , mathematics , psychology , economics , developmental psychology , management , accounting
This report points out that some sibling genetic risk parameters can be regarded as the ratios of the characteristic values in the ascertainment subpopulation. Based on this observation, we reconsider Olson and Cordell's ([2000] Genet. Epidemiol. 18:217–235) and Cordell and Olson's ([2000] Genet. Epidemiol. 18:307–321) estimators, and re‐derive these estimators. Furthermore, we provide the closed‐form variance estimators. Simulation results suggest that our proposed estimators perform very well, and single ascertainment may be better than complete ascertainment for estimating these genetic parameters. © 2004 Wiley‐Liss, Inc.