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Hierarchical Bayes model for random haplotype and family effects in the transmission of fragile‐X
Author(s) -
Huggins R.M.,
Loesch D.Z.,
Qian G.Q.,
Bui Q.M.,
Mitchell R.J.,
Dobson M.,
Taylor A.K.
Publication year - 2004
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.10316
Subject(s) - haplotype , bayes' theorem , genetics , markov chain monte carlo , sequence (biology) , markov chain , biology , transmission (telecommunications) , monte carlo method , computer science , statistics , mathematics , gene , bayesian probability , allele , telecommunications
A model for the transmission of the CGG repeat sequence associated with the fragile‐X dynamic mutation in the FMR1 gene is developed. The model incorporates both haplotype and family effects on the expansion rate of the sequence. The resulting random effects model is fitted to new data, using computer‐intensive Markov chain Monte Carlo methods. The results demonstrate both the FRAXAC1‐DXS458 haplotype and family effects on the transmission of CGG repeats from mother to offspring. © 2004 Wiley‐Liss, Inc.