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Score tests for epistasis models on quantitative traits using general pedigree data
Author(s) -
Wang Kai
Publication year - 2003
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.10266
Subject(s) - pedigree chart , epistasis , score test , likelihood ratio test , statistics , mathematics , computation , maximum likelihood , biology , genetics , algorithm , gene
Efficient score tests for a two‐locus model for quantitative traits are proposed for general pedigrees. Two search strategies, simultaneous search and conditional search, are considered. These tests are attractive alternatives to the likelihood ratio test for their asymptotic equivalency to their respective likelihood ratio tests and efficiency in computation. The finite‐sample properties of these tests are investigated through simulations. Extensions to more complicated models and to other search strategies are discussed. Genet Epidemiol 25:314–326, 2003. © 2003 Wiley‐Liss, Inc.