Premium
Erratum: Broman KW. 2001. Estimation of Allele Frequencies With Data on Sibships. Genet Epidemiol 20:307–15.
Author(s) -
Broman Karl W.
Publication year - 2002
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.10194
Subject(s) - biostatistics , library science , citation , estimation , genealogy , demography , computer science , history , medicine , sociology , engineering , epidemiology , systems engineering
In the April 2001 issue of Genetic Epidemiology, in the article ‘‘Estimation of Allele Frequencies With Data on Sibships,’’ by Broman (20:307–15), there is an error on page 310, in the second paragraph under ‘‘Method 3: Accounting for Relationships.’’ The stated probabilities that an allele in the second sibling is not identical by descent (IBD) with one of the first sibling’s alleles, written as pl/(1+pl), are incorrect; we had missed two important cases. Let (g11, g12) denote the two alleles of the genotype of the first sibling, (g21, g22) denote the two alleles of the genotype of the second sibling, and g1⁄4 (g11, g12, g21, g22). Further, let pg denote the genotypes for the two parents, and A denote the event ‘‘g21 is not IBD with g11 or g12.’’ We seek Pr(A|g), which we calculate by conditioning on the parents’ genotypes, as follows: