Premium
JIL‐1 kinase, a member of the male‐specific lethal (MSL) complex, is necessary for proper dosage compensation of eye pigmentation in Drosophila
Author(s) -
Lerach Stephanie,
Zhang Weiguo,
Deng Huai,
Bao Xiaomin,
Girton Jack,
Johansen Jørgen,
Johansen Kristen M.
Publication year - 2005
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/gene.20172
Subject(s) - compensation (psychology) , biology , kinase , microbiology and biotechnology , genetics , psychology , psychoanalysis
The upregulation of the JIL‐1 kinase on the male X chromosome and its association with the male‐specific lethal (MSL) complex suggest that JIL‐1 may play a role in regulating dosage compensation. To directly test this hypothesis we measured eye pigment levels of mutants in the X‐linked white gene in an allelic series of JIL‐1 hypomorphic mutants. We show that dosage compensation of w a alleles that normally do exhibit dosage compensation was severely impaired in the JIL‐1 mutant backgrounds. As a control we also examined a hypomorphic white allele w e that fails to dosage compensate in males due to a pogo element insertion. In this case the relative pigment level measured in males as compared to females remained approximately the same even in the most severe JIL‐1 hypomorphic background. These results indicate that proper dosage compensation of eye pigment levels in males controlled by X‐linked white alleles requires normal JIL‐1 function. genesis 43:213–215, 2005. © 2005 Wiley‐Liss, Inc.