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Patched 1 conditional null allele in mice
Author(s) -
Ellis Tammy,
Smyth Ian,
Riley Emily,
Graham Scott,
Elliot Kate,
Narang Monica,
Kay Graham F.,
Wicking Carol,
Wainwright Brandon
Publication year - 2003
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/gene.10208
Subject(s) - patched , hedgehog , biology , null allele , hedgehog signaling pathway , allele , conditional gene knockout , sonic hedgehog , gene , genetics , phenotype , gene targeting , microbiology and biotechnology
Abstract Summary: The patched gene ( Ptc ) is a member of the hedgehog signaling pathway which plays a central role in the development of many invertebrate and vertebrate tissues. In addition, Ptc and a number of other pathway members are mutated in some common human cancers. Patched is the receptor for the hedgehog ligand and in the mouse ablation of the Ptc gene leads to developmental defects and an embryonic lethal phenotype. Here we describe a conditional Ptc allele in mice which will have utility for the temporospatial ablation of Ptc function. genesis 36:158–161, 2003. © 2003 Wiley‐Liss, Inc.