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Modulating skeletal muscle mass by postnatal, muscle‐specific inactivation of the myostatin gene
Author(s) -
Grobet Luc,
Pirottin Dimitri,
Farnir Frédéric,
Poncelet Dominique,
Royo Luis Jose,
Brouwers Benoît,
Christians Elisabeth,
Desmecht Daniel,
Coignoul Freddy,
Kahn Ronald,
Georges Michel
Publication year - 2003
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/gene.10188
Subject(s) - myostatin , muscle hypertrophy , myokine , skeletal muscle , biology , conditional gene knockout , endocrinology , medicine , myocyte , wasting , gene , growth differentiation factor , microbiology and biotechnology , genetics , bone morphogenetic protein , phenotype
By using a conditional gene targeting approach exploiting the cre‐lox system, we show that postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a generalized muscular hypertrophy of the same magnitude as that observed for constitutive myostatin knockout mice. This formally demonstrates that striated muscle is the production site of functional myostatin and that this member of the TGFβ family of growth and differentiation factors regulates muscle mass not only during early embryogenesis but throughout development. It indicates that myostatin antagonist could be used to treat muscle wasting and to promote muscle growth in man and animals. genesis 35:227–238, 2003. © 2003 Wiley‐Liss, Inc.