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A human CD2 minigene directs CRE‐mediated recombination in T cells in vivo
Author(s) -
Wilson Trevor J.,
Cowdery Helen E.,
Xu Dakang,
Kola Ismail,
Hertzog Paul J.
Publication year - 2002
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/gene.10107
Subject(s) - minigene , cre recombinase , biology , thymocyte , recombinase , microbiology and biotechnology , recombination activating gene , recombination , spleen , genetically modified mouse , transgene , gene , t cell , genetics , messenger rna , immunology , alternative splicing , immune system
Abstract Summary: We have produced a mouse line that expresses the Cre recombinase under the regulation of a human CD2 minigene to facilitate Cre‐specific recombination in T lymphocytes. These mice express Cre in thymocytes and T cells and are capable of efficient site‐specific recombination as shown in the spleen and thymus, but not other tissues. These mice thus provide an excellent resource for the study of gene function during thymocyte development and in mature T cells. genesis 33:181–184, 2002. © 2002 Wiley‐Liss, Inc.