Open AccessMussel‐Inspired Adhesive Polydopamine‐Functionalized Hyaluronic Acid Hydrogel with Potential Bacterial Inhibition
Author(s) -
Yu QiHang,
Zhang ChenMing,
Jiang ZhiWei,
Qin SiYong,
Zhang AiQing
Publication year - 2020
Publication title -
global challenges
Language(s) - English
Resource type - Journals
ISSN - 2056-6646
DOI - 10.1002/gch2.201900068
Subject(s) - hyaluronic acid , self healing hydrogels , biocompatibility , adhesive , adhesion , tissue adhesion , chemistry , chemical engineering , nanotechnology , materials science , polymer chemistry , organic chemistry , anatomy , layer (electronics) , medicine , engineering
Hyaluronic acid (HA)‐based hydrogels have been receiving increasing attention for wound management. However, pure HA hydrogels usually exhibit weak mechanical strength and poor anti‐infection. Herein, a hybrid HA‐based hydrogel (PDA‐HA) comprised of polydopamine (PDA) and thiolated hyaluronic acid (HA‐SH) is developed based on the Michael addition reaction. The introduction of PDA into HA hydrogel can decrease the critical gel concentration, improve the cell affinity and tissue adhesion, as well as endow the hydrogel with efficient free‐radical scavenging ability. Combining the merits of good biocompatibility and moist environment from HA hydrogel with excellent tissue adhesiveness and free radical scavenging capability from PDA, this cross‐linked PDA‐HA hybrid hydrogel exhibits great potential for creating antimicrobial wound medical dressings.