Open AccessFabrication of Composite Hydrogels Based on Soy Protein Isolate and their Controlled Globular Protein Delivery
Author(s) -
He Naipu,
Chen Xiunan,
Wang Li,
Wen Jing,
Li Yuhong,
Cao Qi,
Liu Zaiman,
Li Baiyu
Publication year - 2019
Publication title -
global challenges
Language(s) - English
Resource type - Journals
ISSN - 2056-6646
DOI - 10.1002/gch2.201900030
Subject(s) - self healing hydrogels , polyacrylic acid , glutaraldehyde , composite number , adsorption , acrylic acid , chemical engineering , protein adsorption , polymer chemistry , monomer , bovine serum albumin , soy protein , materials science , chemistry , absorption of water , polymer , nuclear chemistry , chromatography , organic chemistry , composite material , biochemistry , engineering
Soy protein isolate (SPI) protein/polymer composite hydrogels (PPCGs) are fabricated in a urea solution of SPI using acrylic acid as monomer, ammonium persulphate (APS) as initiator, and N , N ‐methylenebisacrylamide (BIS) and glutaraldehyde (GA) as cross‐linking agents. The scanning electron microscope (SEM) results show that SPI/polyacrylic (PAA) composite hydrogels formed network structure. In particular, in the absence of cross‐linking agent (GA), the network structure of composite hydrogels is also formed by BIS cross‐linking chains of PAA and the hydrophobic interactions between peptides from SPI and chain of PAA. In addition, composite hydrogels have good water absorption and present excellent pH sensitivity. Composite hydrogels adsorb bovine serum albumin (BSA) with higher adsorption capacity. BSA is the control released in pH 7.4 buffers and the accumulative release ratio achieved is 90%. It will be expected that these protein/polymer composite hydrogels could be applied for drug sustained release materials.