Open AccessSustainable Drug Delivery of Famotidine Using Chitosan‐Functionalized Graphene Oxide as Nanocarrier
Author(s) -
Mahajan Chetan Ramesh,
Joshi Lalit B.,
Varma Umakant,
Naik Jitendra B.,
Chaudhari Vijay Raman,
Mishra Satyendra
Publication year - 2019
Publication title -
global challenges
Language(s) - English
Resource type - Journals
ISSN - 2056-6646
DOI - 10.1002/gch2.201900002
Subject(s) - nanocarriers , graphene , famotidine , chitosan , fourier transform infrared spectroscopy , drug delivery , materials science , chemical engineering , oxide , dissolution , nanotechnology , nuclear chemistry , chemistry , pharmacology , medicine , engineering , metallurgy
This work mainly focuses on the graphene oxide (GO)‐assisted sustainable drug delivery of famotidine (FMT) drug. Famotidine is loaded onto GO and encapsulated by chitosan (CH). UV‐visible spectroscopy, field emission scan electron microscopy, and atomic force microscopy confirm the loading of FMT on GO. An interaction of FMT with GO and CH through amine functionalities is confirmed by Fourier‐transform infrared spectroscopy. Differential scanning calorimetric and cyclic voltammetric investigations confirm the compatibility of FMT and its retaining activity within chitosan‐functionalized graphene oxide (CHGO) composite. Encapsulation efficiency of FMT is determined for various CHGO‐FMT combinations and found to be higher at 1:9 ratio. The in vitro drug release profile is studied using a dissolution test apparatus in 0.1 m phosphate buffer medium (pH = 4.5), which shows sustainable drug release up to 12 h, which is greater than the market product (Complete release within 2 h). Comparative study of drug encapsulated with CH and without GO elucidates that GO is responsible for the sustainable release. The “ n ” value obtained from slope using Korsmeyer–Peppas model suggests the super case‐II transport mechanism.